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KMID : 1234920180180020074
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Journal of Korean Oriental Association for Study of Obesity
2018 Volume.18 No. 2 p.74 ~ p.82
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The Protective Effects of Silbi-um Extract on the Alcoholic Liver Injury in Rats
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Kim Bum-Hoi
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Abstract
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Objectives: The objective of this study is to investigate the effects of Silbi-um (SBU) extract on the alcoholic fatty liver induced by EtOH administration for 8 weeks.
Methods: Male Sprague Dawley rats were used. All animals were randomly divided into 3 groups; Normal, EtOH and EtOH+SBU. The rats of EtOH group were daily treated with ethanol of 25% (v/v) for 8 weeks (n=10). EtOH+SBU group was orally treated with SBU water extract after ethanol administration (n=10). The rats of Normal group were treated with saline (n=10). After 8 weeks, the mean body weight, liver weight, and liver-body weight ratio were calculated. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of all groups were measured. The morphological alterations were observed using hematoxylin and eosin (H&E) and Oil Red O staining. Moreover, the alteration of tumor necrosis factor-α (TNF-α) levels were analyzed immunohistochemistrically.
Results: The histological data showed that liver sections from EtOH group displayed severe steatosis. SBU extract significantly inhibited the progression of the alcoholic liver injury. The increased serum level of ALT and AST induced by ethanol administration were decreased by SBU extract. Furthermore, SBU extract significantly decreased the liver concentrations of TNF-α.
Conclusions: SBU water extract attenuated the alcohol induced fatty liver by improving hepatic lipid metabolism via suppression of TNF-α protein. SBU could be effective in protecting the liver from alcoholic fatty liver.
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KEYWORD
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Alcoholic fatty liver, Silbi-um, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Tumor necrosis factor-α (TNF-α)
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